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Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class used primarily in treatment of high blood pressure, heart failure, and after heart attacks. Find out how lisinopril treats high blood pressure (hypertension) and heart failure, and how to take it. Its indications, contraindications, and side effects are as those for all ACE inhibitors Zestril is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. By Maia Szalavitz on September 19, 2022. About lisinopril Who can and cannot take it How and when to take it Side effects Pregnancy, breastfeeding and fertility Taking lisinopril with other medicines and herbal supplements Common questions Stroke. Lisinopril is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. 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